It is the fourth film in the Dr. Dolittle series, and the second film in the series not to feature Eddie Murphy as Doctor Dolittle, or Raven-Symoné as Charisse Dolittle, although Doctor Dolittle (but not Charisse Dolittle) has been mentioned in the film. The film continues to tell the story of a young woman (Kyla Pratt) who talks to animals helps the president (Peter Coyote) of the United States.