Like the original series, the show is set in the same house in San Francisco, California. Recently widowed D.J. Tanner-Fuller is a veterinarian and the mother of three young boys. After the unexpected death of her husband Tommy, who was following his hazardous duties as a firefighter, D.J. accepts the help of her sister Stephanie and best friend Kimmy, who move in and take part in raising D.J.'s three sons, 13-year-old Jackson, 7-year-old Max, and baby Tommy Jr. Kimmy's teenage daughter, Ramona, also moves in.