After losing their job at Columbia University, three Misfit parapsychologists Peter Venkman, Raymond Stantz, and Egon Spengler invent a hightech equipment to capture ghosts and set up a business providing a paranormal investigation service known as "Ghostbusters". They build their fame case by case and hire a fourth member, Winston Zeddemore. But things are not easy when an explosion releases hundreds of ghosts they have captured.